Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed to identify the effects of stigmasterol on ex...

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Bibliographic Details
Main Authors: Shuting Wen, Long He, Zhuotai Zhong, Runyuan Zhao, Senhui Weng, Hong Mi, Fengbin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
stigmasterol
microbiota
butyrate
PPARγ
Treg/Th17 balance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.741934/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.741934/full

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