Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neuro...

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Bibliographic Details
Main Authors: Souhel Najjar, Silky Pahlajani, Virginia De Sanctis, Joel N. H. Stern, Amanda Najjar, Derek Chong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00083/full