C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways.

C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways.

A recent phase I clinical trial (SCIPIO) has shown that autologous c-kit+ cardiac progenitor cells (CPCs) improve cardiac function and quality of life when transplanted into patients with ischemic heart disease. Although c-kit is widely used as a marker of resident CPCs, its role in the regulation o...

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Bibliographic Details
Main Authors: Bathri N Vajravelu, Kyung U Hong, Tareq Al-Maqtari, Pengxiao Cao, Matthew C L Keith, Marcin Wysoczynski, John Zhao, Joseph B Moore, Roberto Bolli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608800?pdf=render

Internet

http://europepmc.org/articles/PMC4608800?pdf=render

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