Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells.

Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells.

BACKGROUND:The cellular prion protein (PrP(C)) plays a key role in the pathogenesis of Transmissible Spongiform Encephalopathies in which the protein undergoes post-translational conversion to the infectious form (PrP(Sc)). Although endocytosis appears to be required for this conversion, the mechani...

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Bibliographic Details
Main Authors: Daniela Sarnataro, Anna Caputo, Philippe Casanova, Claudia Puri, Simona Paladino, Simona S Tivodar, Vincenza Campana, Carlo Tacchetti, Chiara Zurzolo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2688078?pdf=render

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http://europepmc.org/articles/PMC2688078?pdf=render

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