Oncometabolic Nuclear Reprogramming of Cancer Stemness

Oncometabolic Nuclear Reprogramming of Cancer Stemness

By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live c...

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Bibliographic Details
Main Authors: Javier A. Menendez, Bruna Corominas-Faja, Elisabet Cuyàs, María G. García, Salvador Fernández-Arroyo, Agustín F. Fernández, Jorge Joven, Mario F. Fraga, Tomás Alarcón
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Stem Cell Reports
Subjects:
Oncometabolites
reprogramming
stemness
cancer
stem cells
cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111500377X

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http://www.sciencedirect.com/science/article/pii/S221367111500377X

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