Oncometabolic Nuclear Reprogramming of Cancer Stemness
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live c...
Main Authors: | Javier A. Menendez, Bruna Corominas-Faja, Elisabet Cuyàs, María G. García, Salvador Fernández-Arroyo, Agustín F. Fernández, Jorge Joven, Mario F. Fraga, Tomás Alarcón |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-03-01
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Series: | Stem Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221367111500377X |
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