Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial

Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Severe TBI, defined as a Glasgow Coma Scale ≤ 8, increases intracranial pressure and activates the sympathetic nervous system. Sympathetic hyperactivity after TBI manifests as catecholamine excess, hypertension, abnormal heart rate v...

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Bibliographic Details
Main Authors: Patel Mayur B, McKenna John W, Alvarez JoAnn M, Sugiura Ayaka, Jenkins Judith M, Guillamondegui Oscar D, Pandharipande Pratik P
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Trials
Subjects:
Traumatic brain injury
Sympathetic hyperactivity
Sympathetic storm
Autonomic dysfunction
Adrenergic blockade
Beta-blocker
Alpha<sub>2</sub>-agonist
Propranolol
Clonidine
Agitation
Online Access:http://www.trialsjournal.com/content/13/1/177

Internet

http://www.trialsjournal.com/content/13/1/177

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