Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

Abstract Background Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated transcription. Here, we explore the relationship between the folding of promoter G4s, transcription and chromatin state. Resul...

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Bibliographic Details
Main Authors: Jiazhen Shen, Dhaval Varshney, Angela Simeone, Xiaoyun Zhang, Santosh Adhikari, David Tannahill, Shankar Balasubramanian
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Biology
Subjects:
G-quadruplexes
Transcription
RNA polymerase II
Chromatin compaction
Online Access:https://doi.org/10.1186/s13059-021-02346-7

Internet

https://doi.org/10.1186/s13059-021-02346-7

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