Interaction of the capsular polysaccharide A from Bacteroides fragilis with DC-SIGN on human dendritic cells is necessary for its processing and presentation to T cells.

Interaction of the capsular polysaccharide A from Bacteroides fragilis with DC-SIGN on human dendritic cells is necessary for its processing and presentation to T cells.

The zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis is the first carbohydrate antigen described to be presented in major histocompatibility complex (MHC) class II for the induction of CD4+ T cell responses. However, the identity of the receptor mediating binding and internalizat...

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Bibliographic Details
Main Authors: Karien eBloem, Juan J Garcia-Vallejo, Ilona M Vuist, Brian eCobb, Sandra J van Vliet, Yvette eVan Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
T cell proliferation
pathogen
C-type lectin
polysaccharide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00103/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00103/full

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