Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII

Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII

Recombinant FVIII manufacturing is characterized by poor product stability and low yields. Codon-optimization of transgenes accelerates translation by exploiting the synonymous codon usage bias of a species. However, this can alter the performance of the final product. Additionally, the effects of t...

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Bibliographic Details
Main Authors: Bredon Crawford, Margareth C Ozelo, Kenichi Ogiwara, James Ahlin, Silvia Albanez, Carol Hegadorn, Lori Harpell, Christine Hough, David Lillicrap
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300456

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http://www.sciencedirect.com/science/article/pii/S2329050116300456

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