The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei

The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei

Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and drug-resistance. In this study, we explored t...

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Bibliographic Details
Main Authors: Hazel Xinyu Koh, Htay Mon Aye, Kevin S. W. Tan, Cynthia Y. He
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-07-01
Series:Microbial Cell
Subjects:
Trypanosoma brucei
LeuLeu-OMe
lysosome
lysosomotropic
necrosis
autophagy
Online Access:http://microbialcell.com/researcharticles/the-lysosomotropic-drug-leuleu-ome-induces-lysosome-disruption-and-autophagy-independent-cell-death-in-trypanosoma-brucei/

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http://microbialcell.com/researcharticles/the-lysosomotropic-drug-leuleu-ome-induces-lysosome-disruption-and-autophagy-independent-cell-death-in-trypanosoma-brucei/

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