Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

Abstract Background Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increased in chronic inflammation and autoimmunity and may instead have patho...

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Bibliographic Details
Main Authors: Uta Hardt, Anders Larsson, Iva Gunnarsson, Robert M. Clancy, Michelle Petri, Jill P. Buyon, Gregg J. Silverman, Elisabet Svenungsson, Caroline Grönwall
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Arthritis Research & Therapy
Subjects:
Autoantibodies
Natural antibodies
Malondialdehyde protein modification
SLE
Lupus nephritis
Disease activity
Online Access:http://link.springer.com/article/10.1186/s13075-018-1530-2

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http://link.springer.com/article/10.1186/s13075-018-1530-2

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