Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats

Abstract Background Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced lung injury (VILI). Piezo1 is a key element of the mechanotransduction process and can transduce mechanical signals into biological signals by mediating Ca2+ influx, which in turn regul...

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Bibliographic Details
Main Authors: Yang Zhang, Lulu Jiang, Tianfeng Huang, Dahao Lu, Yue Song, Lihui Wang, Ju Gao
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-021-01844-3