Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

Metabolic imaging of brain tumors using 13C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-13C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clinical trials in multiple centers. Typically, the pre...

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Bibliographic Details
Main Authors: Myriam M. Chaumeil, Marina Radoul, Chloé Najac, Pia Eriksson, Pavithra Viswanath, Michael D. Blough, Charles Chesnelong, H. Artee Luchman, J. Gregory Cairncross, Sabrina M. Ronen
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:NeuroImage: Clinical
Subjects:
Glioma
Isocitrate dehydrogenase 1 (IDH1) mutation
Metabolic reprogramming
Hyperpolarized 13C Magnetic Resonance Spectroscopy (MRS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158216301164

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http://www.sciencedirect.com/science/article/pii/S2213158216301164

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