Nicotine and its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation

Nicotine and its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation

Nicotine is a major constituent of cigarette smoke. Its primary metabolite in maternal and cord sera, cotinine, is considered a biomarker of prenatal smoking. Nicotine and cotinine half-lives are decreased in pregnancy due to their increased rate of metabolism and conversion to downstream metabolite...

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Bibliographic Details
Main Authors: Parnian Kheirkhah Rahimabad, Thilani M. Anthony, A. Daniel Jones, Shakiba Eslamimehr, Nandini Mukherjee, Susan Ewart, John W. Holloway, Hasan Arshad, Sarah Commodore, Wilfried Karmaus
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Environmental Research and Public Health
Subjects:
prenatal smoking exposure
nicotine
maternal serum
cord serum
DNA methylation
Online Access:https://www.mdpi.com/1660-4601/17/24/9552

Internet

https://www.mdpi.com/1660-4601/17/24/9552

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