Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

Summary: Reversible differentiation of vascular smooth muscle cells (VSMCs) plays a critical role in vascular biology and disease. Changes in VSMC differentiation correlate with stiffness of the arterial extracellular matrix (ECM), but causal relationships remain unclear. We show that VSMC plasticit...

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Bibliographic Details
Main Authors: Shefali Talwar, Aayush Kant, Tina Xu, Vivek B. Shenoy, Richard K. Assoian
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
computational simulation
mathematical modeling
differentiation
contractile force
proliferation
mechanotransduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003338

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http://www.sciencedirect.com/science/article/pii/S2211124721003338

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