Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

Rai et al. characterise the properties of secreted midbody remnants, showing they are distinct from exosomes and microvesicles. The authors also find that these vesicles are engulfed by cells and promote anchorage independent growth and invasive phenotypes in NIH3T3 fibroblasts.

Bibliographic Details
Main Authors: Alin Rai, David W. Greening, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, Richard J. Simpson
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01882-z
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spelling doaj-d513646f659d46ada6d3d94fad6062e72021-03-28T11:24:30ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111210.1038/s42003-021-01882-zSecreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticlesAlin Rai0David W. Greening1Rong Xu2Maoshan Chen3Wittaya Suwakulsiri4Richard J. Simpson5Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe UniversityRai et al. characterise the properties of secreted midbody remnants, showing they are distinct from exosomes and microvesicles. The authors also find that these vesicles are engulfed by cells and promote anchorage independent growth and invasive phenotypes in NIH3T3 fibroblasts.https://doi.org/10.1038/s42003-021-01882-z
collection DOAJ
language English
format Article
sources DOAJ
author Alin Rai
David W. Greening
Rong Xu
Maoshan Chen
Wittaya Suwakulsiri
Richard J. Simpson
spellingShingle Alin Rai
David W. Greening
Rong Xu
Maoshan Chen
Wittaya Suwakulsiri
Richard J. Simpson
Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
Communications Biology
author_facet Alin Rai
David W. Greening
Rong Xu
Maoshan Chen
Wittaya Suwakulsiri
Richard J. Simpson
author_sort Alin Rai
title Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
title_short Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
title_full Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
title_fullStr Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
title_full_unstemmed Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
title_sort secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-03-01
description Rai et al. characterise the properties of secreted midbody remnants, showing they are distinct from exosomes and microvesicles. The authors also find that these vesicles are engulfed by cells and promote anchorage independent growth and invasive phenotypes in NIH3T3 fibroblasts.
url https://doi.org/10.1038/s42003-021-01882-z
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AT rongxu secretedmidbodyremnantsareaclassofextracellularvesiclesmolecularlydistinctfromexosomesandmicroparticles
AT maoshanchen secretedmidbodyremnantsareaclassofextracellularvesiclesmolecularlydistinctfromexosomesandmicroparticles
AT wittayasuwakulsiri secretedmidbodyremnantsareaclassofextracellularvesiclesmolecularlydistinctfromexosomesandmicroparticles
AT richardjsimpson secretedmidbodyremnantsareaclassofextracellularvesiclesmolecularlydistinctfromexosomesandmicroparticles
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