Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

Cancer cells can adapt to nutrient poor conditions by rewiring their metabolism and using alternate fuel sources. Identifying these adaptive metabolic pathways may provide novel targets for cancer therapy. Here, we identify a subset of non-small cell lung cancer (NSCLC) cell lines that survive in th...

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Bibliographic Details
Main Authors: Cindy Hodakoski, Benjamin D. Hopkins, Guoan Zhang, Taojunfeng Su, Zhe Cheng, Roxanne Morris, Kyu Y. Rhee, Marcus D. Goncalves, Lewis C. Cantley
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
macropinocytosis
Rac
metabolism
glucose
Online Access:http://www.mdpi.com/2072-6694/11/1/37

Internet

http://www.mdpi.com/2072-6694/11/1/37

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