In Silico Drug Repurposing by Structural Alteration after Induced Fit: Discovery of a Candidate Agent for Recovery of Nucleotide Excision Repair in Xeroderma Pigmentosum Group D Mutant (R683W)

In Silico Drug Repurposing by Structural Alteration after Induced Fit: Discovery of a Candidate Agent for Recovery of Nucleotide Excision Repair in Xeroderma Pigmentosum Group D Mutant (R683W)

Xeroderma pigmentosum complementation group D (XPD) is a UV-sensitive syndrome and a rare incurable genetic disease which is caused by the genetic mutation of the excision repair cross-complementation group 2 gene (<i>ERCC2</i>). Patients who harbor only XPD R683W mutant protein develop...

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Bibliographic Details
Main Authors: Yutaka Takaoka, Mika Ohta, Satoshi Tateishi, Aki Sugano, Eiji Nakano, Kenji Miura, Takashi Suzuki, Chikako Nishigori
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
drug repurposing
induced fit
molecular dynamics simulation
xeroderma pigmentosum complementation group D
ATP binding
4E1RCat
Online Access:https://www.mdpi.com/2227-9059/9/3/249

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https://www.mdpi.com/2227-9059/9/3/249

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