A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.

Nuclear factor of activated T cells (NFAT) plays a critical role in the development and function of immune and non-immune cells. Although NFAT is a central transcriptional regulator of T cell cytokines, its role in macrophage specific gene expression is less defined. Previous work from our group dem...

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Bibliographic Details
Main Authors: Houda Z Elloumi, Nitsan Maharshak, Kavitha N Rao, Taku Kobayashi, Hyungjin S Ryu, Marcus Mühlbauer, Fengling Li, Christian Jobin, Scott E Plevy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3313977?pdf=render