Decreased α7nAChR mRNA levels in peripheral blood monocytes are associated with enhanced inflammatory cytokine production in patients with lupus nephritis

Decreased α7nAChR mRNA levels in peripheral blood monocytes are associated with enhanced inflammatory cytokine production in patients with lupus nephritis

The cholinergic anti-inflammatory pathway modulates cytokine release by activating alpha-7 nicotinic acetylcholine receptors (α7nAChR) in monocytes/macrophages. We aimed to determine the role of α7nAChR in lupus nephritis (LN). We enrolled 36 inactive and 35 active LN patients, 34 primary glomerulon...

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Bibliographic Details
Main Authors: Hongmei Xu, Jia Li, Li Zhang, Nan Li, Sensen Su, Zhuang Ye, Ying Xu
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
α7nAChR
Lupus nephritis
Peripheral monocyte
Inflammation
Cytokine
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218376157

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http://www.sciencedirect.com/science/article/pii/S0753332218376157

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