Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2

Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2

The corticospinal tract (CST) plays an important role in controlling voluntary movement. Because the CST has a long trajectory throughout the brain toward the spinal cord, many axon guidance molecules are required to navigate the axons correctly during development. Previously, we found that double-k...

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Bibliographic Details
Main Authors: Satoshi Aizawa, Takuya Okada, Kazuko Keino-Masu, Tri Huu Doan, Tadachika Koganezawa, Masahiro Akiyama, Akira Tamaoka, Masayuki Masu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
heparan sulfate
Sulfatase 1
Sulfatase 2
knockout mouse
corticospinal tract
pyramidal decussation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00333/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00333/full

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