Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231

Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231

Normally, bone sialoprotein (BSP) is an important contributor to bone micro-calcification. However, it is also highly expressed in bone-metastatic malignancies, including prostate, lung, and breast cancer. In these disorders, BSP correlates with poor prognosis. Its expression in triple-negative brea...

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Bibliographic Details
Main Authors: Valeh Rustamov, Florian Keller, Julia Klicks, Mathias Hafner, Rüdiger Rudolf
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
BSP
bone sialoprotein
breast cancer
MDA-MB-231
spheroid
3D cell culture
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00036/full

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