E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain

E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain

ABSTRACT UHRF2 is a ubiquitin-protein ligase E3 that regulates cell cycle, genomic stability and epigenetics. We conducted a co-immunoprecipitation assay and found that TIP60 and HDAC1 interact with UHRF2. We previously demonstrated that UHRF2 regulated H3K9ac and H3K14ac differentially in normal an...

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Bibliographic Details
Main Authors: Shengyuan Zeng, Yangyang Wang, Ting Zhang, Lu Bai, Yalan Wang, Changzhu Duan
Format: Article
Language:English
Published: SpringerOpen 2016-10-01
Series:Protein & Cell
Subjects:
UHRF2
TIP60
ubiquitination
acetylation
hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1007/s13238-016-0324-z

Internet

http://link.springer.com/article/10.1007/s13238-016-0324-z

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