Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract
Prunus mahaleb L. is a marginal fruit crop producing cherry-like dark purple drupes with a very bitter taste, rich in polyphenolic compounds. A mahaleb fruit concentrated extract (mfce) has been assayed for its biological activities. In this work, we report results on the in vitro effects of mfce in...
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doaj-d5225fbd829f427d8508b3aca5f6d36c2021-04-30T07:08:52ZengElsevierJournal of Functional Foods1756-46462016-12-0127537548Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extractCarmela Gerardi0Stefania Frassinetti1Leonardo Caltavuturo2Antonella Leone3Raffaella Lecci4Nadia Calabriso5Maria Annunziata Carluccio6Federica Blando7Giovanni Mita8Institute of Sciences of Food Production, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy; Corresponding author. Institute of Sciences of Food Production, CNR, Lecce Unit, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy. Fax: +39 0832 422620.Institute of Biology and Agricultural Biotechnology, CNR, via Moruzzi, 1 56124 Pisa, ItalyInstitute of Biology and Agricultural Biotechnology, CNR, via Moruzzi, 1 56124 Pisa, ItalyInstitute of Sciences of Food Production, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyInstitute of Sciences of Food Production, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyInstitute of Clinical Physiology, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyInstitute of Clinical Physiology, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyInstitute of Sciences of Food Production, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyInstitute of Sciences of Food Production, CNR, via Prov.le Lecce-Monteroni, 73100 Lecce, ItalyPrunus mahaleb L. is a marginal fruit crop producing cherry-like dark purple drupes with a very bitter taste, rich in polyphenolic compounds. A mahaleb fruit concentrated extract (mfce) has been assayed for its biological activities. In this work, we report results on the in vitro effects of mfce including: i) anti-proliferative, gap junction intercellular communication (GJIC) modulation and pro-apoptotic properties in a breast cancer cell line (MCF-7), ii) anti-inflammatory properties in human vascular endothelial cells (HUVEC), iii) anti-mutagenic effect on yeast Saccharomyces cerevisiae strain D7. Mfce exerted a dose-dependent anti-proliferative effect on MCF-7 cells together with a significant time-dependent increase in GJIC and a pro-apoptotic effect. Furthermore, mfce significantly reduced levels of endothelial inflammatory antigens in a concentration-dependent manner. Finally, mfce protected S. cerevisiae cells against H2O2 cytotoxicity by direct radical scavenging activity. This study demonstrated multiple healthful biological effects of mfce, highlighting it as a potential nutraceutical product.http://www.sciencedirect.com/science/article/pii/S1756464616303024Pro-apoptotic effectAnti-mutagenic effectGJICICAM-1Prunus mahaleb L. VCAM-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carmela Gerardi Stefania Frassinetti Leonardo Caltavuturo Antonella Leone Raffaella Lecci Nadia Calabriso Maria Annunziata Carluccio Federica Blando Giovanni Mita |
spellingShingle |
Carmela Gerardi Stefania Frassinetti Leonardo Caltavuturo Antonella Leone Raffaella Lecci Nadia Calabriso Maria Annunziata Carluccio Federica Blando Giovanni Mita Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract Journal of Functional Foods Pro-apoptotic effect Anti-mutagenic effect GJIC ICAM-1 Prunus mahaleb L. VCAM-1 |
author_facet |
Carmela Gerardi Stefania Frassinetti Leonardo Caltavuturo Antonella Leone Raffaella Lecci Nadia Calabriso Maria Annunziata Carluccio Federica Blando Giovanni Mita |
author_sort |
Carmela Gerardi |
title |
Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract |
title_short |
Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract |
title_full |
Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract |
title_fullStr |
Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract |
title_full_unstemmed |
Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract |
title_sort |
anti-proliferative, anti-inflammatory and anti-mutagenic activities of a prunus mahaleb l. anthocyanin-rich fruit extract |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2016-12-01 |
description |
Prunus mahaleb L. is a marginal fruit crop producing cherry-like dark purple drupes with a very bitter taste, rich in polyphenolic compounds. A mahaleb fruit concentrated extract (mfce) has been assayed for its biological activities. In this work, we report results on the in vitro effects of mfce including: i) anti-proliferative, gap junction intercellular communication (GJIC) modulation and pro-apoptotic properties in a breast cancer cell line (MCF-7), ii) anti-inflammatory properties in human vascular endothelial cells (HUVEC), iii) anti-mutagenic effect on yeast Saccharomyces cerevisiae strain D7. Mfce exerted a dose-dependent anti-proliferative effect on MCF-7 cells together with a significant time-dependent increase in GJIC and a pro-apoptotic effect. Furthermore, mfce significantly reduced levels of endothelial inflammatory antigens in a concentration-dependent manner. Finally, mfce protected S. cerevisiae cells against H2O2 cytotoxicity by direct radical scavenging activity. This study demonstrated multiple healthful biological effects of mfce, highlighting it as a potential nutraceutical product. |
topic |
Pro-apoptotic effect Anti-mutagenic effect GJIC ICAM-1 Prunus mahaleb L. VCAM-1 |
url |
http://www.sciencedirect.com/science/article/pii/S1756464616303024 |
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