HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4

HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4

Abstract Background Chemo-resistance of bladder cancer has been considered to be one of the serious issues to be solved. In this study, we revealed pivotal role of miR-424 in the regulation of CDDP sensitivity of bladder cancer cells. Methods The cytotoxicity of cisplatin and effect of miR-424 were...

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Bibliographic Details
Main Authors: Meng Yu, Toshinori Ozaki, Dan Sun, Haotian Xing, Baojun Wei, Jun An, Jieping Yang, Ying Gao, Shuangjie Liu, Chuize Kong, Yuyan Zhu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
miR-424
UNC5B
SIRT4
HIF-1α
Cisplatin
Bladder cancer
Online Access:http://link.springer.com/article/10.1186/s13046-020-01613-y

Internet

http://link.springer.com/article/10.1186/s13046-020-01613-y

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