RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.

Bibliographic Details
Main Authors: Christine Wolf, Alexander Rapp, Nicole Berndt, Wolfgang Staroske, Max Schuster, Manuela Dobrick-Mattheuer, Stefanie Kretschmer, Nadja König, Thomas Kurth, Dagmar Wieczorek, Karin Kast, M. Cristina Cardoso, Claudia Günther, Min Ae Lee-Kirsch
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11752

Internet

https://doi.org/10.1038/ncomms11752

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