RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.
Bibliographic Details
Main Authors: |
Christine Wolf,
Alexander Rapp,
Nicole Berndt,
Wolfgang Staroske,
Max Schuster,
Manuela Dobrick-Mattheuer,
Stefanie Kretschmer,
Nadja König,
Thomas Kurth,
Dagmar Wieczorek,
Karin Kast,
M. Cristina Cardoso,
Claudia Günther,
Min Ae Lee-Kirsch |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-05-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/ncomms11752
|