Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone

Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone

Abstract Background Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular proteins. Ovarian cancer G protein-coupled receptor 1 (OGR1) senses extracell...

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Bibliographic Details
Main Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima, Tamotsu Ishizuka
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Inflammation
Subjects:
OGR1
Airway smooth muscle cell
Proton
CXCL8
NF-κB
Dexamethasone
Online Access:http://link.springer.com/article/10.1186/s12950-019-0207-1

Internet

http://link.springer.com/article/10.1186/s12950-019-0207-1

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