The Stemness-High Human Colorectal Cancer Cells Promote Angiogenesis by Producing Higher Amounts of Angiogenic Cytokines via Activation of the Egfr/Akt/Nf-κB Pathway

The Stemness-High Human Colorectal Cancer Cells Promote Angiogenesis by Producing Higher Amounts of Angiogenic Cytokines via Activation of the Egfr/Akt/Nf-κB Pathway

Purpose: Cancer stem cells (CSCs) are responsible for cancer metastasis by stimulating tumor angiogenesis via various mechanisms. To elucidate the potential of the stemness-high human colorectal cancer (CRC) cells (i.e., CRCSCs) in activating angiogenesis, effects of the GATA6-overexpressing HCT-116...

Full description

Bibliographic Details
Main Authors: Shin-Yi Chung, Ta-Chung Chao, Yeu Su
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer stem cell
GATA6
angiogenesis
EGFR
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/3/1355

Internet

https://www.mdpi.com/1422-0067/22/3/1355

Similar Items