Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway

Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway

Abstract Background CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, the extracellular domain of MUC16 is released from the cell surface into...

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Bibliographic Details
Main Authors: Isabelle Matte, Perrine Garde-Granger, Paul Bessette, Alain Piché
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
Ascites
Ovarian cancer
MUC16
Mesothelial cells
Online Access:http://link.springer.com/article/10.1186/s12885-019-5611-7

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http://link.springer.com/article/10.1186/s12885-019-5611-7

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