FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer

FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer

Abstract Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine therapy. Mutations in fibroblast growth factor receptor (FGFR) genes have been associ...

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Bibliographic Details
Main Authors: Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej, Hanna Romanska
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Estrogen receptor
Progesterone receptor
Tumour microenvironment
Fibroblast growth factor receptors
Online Access:http://link.springer.com/article/10.1186/s13046-019-1236-6

Internet

http://link.springer.com/article/10.1186/s13046-019-1236-6

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