Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT<sub>1</sub> /AT<sub>2</sub> receptors. In this article, we aimed to explore which me...

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Bibliographic Details
Main Authors: Mariana Ferreira-Duarte, Tiago Rodrigues-Pinto, Teresa Sousa, Miguel A. Faria, Maria Sofia Rocha, Daniela Menezes-Pinto, Marisa Esteves-Monteiro, Fernando Magro, Patrícia Dias-Pereira, Margarida Duarte-Araújo, Manuela Morato
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
inflammatory bowel disease
IBD
TNBS-induced colitis
colonic dysmotility
angiotensin II
AT<sub>1</sub> and AT<sub>2</sub> receptors
Online Access:https://www.mdpi.com/1422-0067/22/9/4836

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https://www.mdpi.com/1422-0067/22/9/4836

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