CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure.
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is normally unmethylated, but a sizeable fraction is prone to become methylated in various cell types and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-03-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1386721?pdf=render |