Sex Hormones Regulate SHANK Expression

Sex Hormones Regulate SHANK Expression

Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding pro...

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Bibliographic Details
Main Authors: Simone Berkel, Ahmed Eltokhi, Henning Fröhlich, Diana Porras-Gonzalez, Rafiullah Rafiullah, Rolf Sprengel, Gudrun A. Rappold
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorders (ASD)
sex differences
SHANK
SH-SY5Y cells
dihydrotestosterone
17β-estradiol
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00337/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00337/full

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