Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

Bibliographic Details
Main Authors: Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15902-9

Internet

https://doi.org/10.1038/s41467-020-15902-9

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