Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing

Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing

Thrombospondin-4 (THBS4) is a non-structural extracellular matrix molecule associated with tissue regeneration and a variety of pathological processes characterized by increased cell proliferation and migration. However, the mechanisms of how THBS4 regulates cell behavior as well as the pathways con...

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Bibliographic Details
Main Authors: Mariliis Klaas, Kristina Mäemets-Allas, Elizabeth Heinmäe, Heli Lagus, Claudia Griselda Cárdenas-León, Terje Arak, Mart Eller, Külli Kingo, Esko Kankuri, Viljar Jaks
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
skin regeneration
wound healing
burns
thrombospondin-4
fibroblasts
psoriasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.745637/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.745637/full

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