Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling

Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling

Trichloroethylene (TCE) is a serious health hazard for workers with daily exposure, causing occupational medicamentosa-like dermatitis due to TCE (OMDT) and glomerular damage. Recent studies suggest that mTORC1 signaling is activated in various glomerular disorders; however, the role of mTORC1 signa...

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Bibliographic Details
Main Authors: Feng Wang, Yuying Dai, Meng Huang, Chenchen Zhang, Liping Huang, Hui Wang, Liangping Ye, Qifeng Wu, Xuejun Zhang, Qixing Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
trichloroethylene
podocyte
apoptosis
mTOR
cathepsin L
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.639878/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.639878/full

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