Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell respon...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05315-0 |