Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression

Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression

Background The effects of non-amplification short variant (SV) mutations in CD274 (programmed death-ligand 1 (PD-L1)) on PD-L1 protein expression and immune checkpoint inhibitors (ICPIs) therapy are unknown. Here, we present a retrospective analysis of CD274 mutations detected by comprehensive genom...

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Bibliographic Details
Main Authors: Brennan Decker, Richard S.P. Huang, Karthikeyan Murugesan, Douglas A. Mata, Jeffrey S. Ross, Matthew Hiemenz, Gerald Li, James Creeden, Shakti H. Ramkissoon
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e002558.full

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https://jitc.bmj.com/content/9/6/e002558.full

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