Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Abstract Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer’s disease (LOAD). Research on APOE4 has mai...

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Bibliographic Details
Main Authors: Raquel Larramona-Arcas, Candela González-Arias, Gertrudis Perea, Antonia Gutiérrez, Javier Vitorica, Tamara García-Barrera, José Luis Gómez-Ariza, Raquel Pascua-Maestro, María Dolores Ganfornina, Eleanna Kara, Eloise Hudry, Marta Martinez-Vicente, Miquel Vila, Elena Galea, Roser Masgrau
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Neurodegeneration
Subjects:
APOE4
Astrocytes
Calcium signaling
Sex
Lysosome
Purinergic receptors
Online Access:http://link.springer.com/article/10.1186/s13024-020-00382-8

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http://link.springer.com/article/10.1186/s13024-020-00382-8

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