Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes

Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes

α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free c...

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Bibliographic Details
Main Authors: Artem A. Zemtsov, Alexander D. Volodin, Vitalij V. Levin, Marina I. Struchkova, Alexander D. Dilman
Format: Article
Language:English
Published: Beilstein-Institut 2015-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
1-bromoalkynes
cross-coupling
organofluorine compounds
organozinc reagents
Online Access:https://doi.org/10.3762/bjoc.11.231

Internet

https://doi.org/10.3762/bjoc.11.231

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