Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family.

Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family.

PDZ domains in general, and those of PSD-95 in particular, are emerging as promising drug targets for diseases such as ischemic stroke. We have previously shown that dimeric ligands that simultaneously target PDZ1 and PDZ2 of PSD-95 are highly potent inhibitors of PSD-95. However, PSD-95 and the rel...

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Bibliographic Details
Main Authors: Klaus B Nissen, Linda M Haugaard-Kedström, Theis S Wilbek, Line S Nielsen, Emma Åberg, Anders S Kristensen, Anders Bach, Per Jemth, Kristian Strømgaard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319893?pdf=render

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http://europepmc.org/articles/PMC4319893?pdf=render

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