Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

AbstractBackground BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus marten...

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Bibliographic Details
Main Authors: Yi-Jun Feng, Qi Feng, Jie Tao, Rong Zhao, Yong-Hua Ji
Format: Article
Language:English
Published: SciELO 2015-11-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
BmK I
BmK IT2
Synergistic effect
Allosteric interactions
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100347&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100347&lng=en&tlng=en

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