Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4+ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis

Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4+ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis

Microsomal prostaglandin synthetase-1 (mPGES-1) is an inducible terminal enzyme that produces prostaglandin E2 (PGE2). In our previous study, we investigated the role of mPGES-1 in the inflammation and demyelination observed in experimental autoimmune encephalomyelitis (EAE), an animal model of mult...

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Bibliographic Details
Main Authors: Takako Takemiya, Chisen Takeuchi, Marumi Kawakami
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin-1β (IL-1β)
prostaglandin E2 (PGE2)
microsomal prostaglandin synthetase-1 (mPGES-1)
mPGES-1-deficient (mPGES-1−/−) mice
CD4-positive T cells (CD4+ T cells)
interleukin-17 (IL-17)
experimental allergic encephalomyelitis (EAE)
multiple sclerosis (MS)
vascular endothelial cells (VECs)
myelin oligodendrocyte glycoprotein35–55 peptide (MOG35–55)
Online Access:https://www.mdpi.com/1422-0067/18/12/2758

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https://www.mdpi.com/1422-0067/18/12/2758

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