Combining tissue and circulating tumor DNA increases the detection rate of a CTNNB1 mutation in hepatocellular carcinoma

Combining tissue and circulating tumor DNA increases the detection rate of a CTNNB1 mutation in hepatocellular carcinoma

Abstract Background and aims Studies suggest that mutations in the CTNNB1 gene are predictive of response to immunotherapy, an emerging therapy for advanced hepatocellular carcinoma (HCC). Analysis of circulating tumor DNA (ctDNA) offers the possibility of serial non-invasive mutational profiling of...

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Bibliographic Details
Main Authors: Stine Karlsen Oversoe, Michelle Simone Clement, Britta Weber, Henning Grønbæk, Stephen Jacques Hamilton-Dutoit, Boe Sandahl Sorensen, Jens Kelsen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Molecular pathology
Circulating tumor DNA
Droplet digital PCR
Predictive biomarkers
Online Access:https://doi.org/10.1186/s12885-021-08103-0

Internet

https://doi.org/10.1186/s12885-021-08103-0

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