Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

Abstract Background Molecular profiling in ovarian cancer (OC) revealed that the desmoplasia subtype presented the poorest prognosis, highlighting the contribution of stromal fibroblasts in tumor progression. This study aimed to investigate the molecular characteristics of SNAI2 driving the transcri...

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Bibliographic Details
Main Authors: Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma, Qinglei Gao
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Cancer
Subjects:
SNAI2
Stromal fibroblast
Reprogram
Stiffness
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s12943-017-0732-6

Internet

http://link.springer.com/article/10.1186/s12943-017-0732-6

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