Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

Summary: Clostridium perfringens epsilon toxin (ETX) is hypothesized to mediate blood-brain barrier (BBB) permeability by binding to the myelin and lymphocyte protein (MAL) on the luminal surface of endothelial cells (ECs). However, the kinetics of this interaction and a general understanding of ETX...

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Bibliographic Details
Main Authors: Drew Adler, Jennifer R. Linden, Samantha V. Shetty, Yinghua Ma, Monika Bokori-Brown, Richard W. Titball, Timothy Vartanian
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219301130