Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species

Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species

Protein aggregation into amyloid deposits and oxidative stress are key features of many neurodegenerative disorders including Parkinson's and Alzheimer's disease. We report here the creation of four highly sensitive bifunctional fluorescent probes, capable of H2O2 and/or amyloid aggregate...

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Bibliographic Details
Main Authors: Lisa-Maria Needham, Judith Weber, James W. B. Fyfe, Omaru M. Kabia, Dung T. Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M. Dobson, Sonia Ghandi, Sarah E. Bohndiek, Thomas N. Snaddon, Steven F. Lee
Format: Article
Language:English
Published: The Royal Society 2018-01-01
Series:Royal Society Open Science
Subjects:
fluorophores
ros
sensors
protein aggregation
single-molecule imaging
thioflavin t
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171399

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171399

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