Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

Plasmodium falciparum infection can abruptly progress to severe malaria, a life-threatening complication resulting from sequestration of parasitized red blood cells (PRBC) in the microvasculature of various organs such as the brain and lungs. PRBC adhesion can induce endothelial cell (EC) activation...

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Bibliographic Details
Main Authors: Estelle S Zang-Edou, Ulrick Bisvigou, Zacharie Taoufiq, Faustin Lékoulou, Jean Bernard Lékana-Douki, Yves Traoré, Dominique Mazier, Fousseyni S Touré-Ndouo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2951358?pdf=render

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http://europepmc.org/articles/PMC2951358?pdf=render

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